The loss dropped the Wildcats to 6-7 on the year. With a 4-3 district mark, the 'Cats are tied with the Lipan Indians for third place.
The tie won't last long, however, as Lipan visits Santo tonight for a game that will significantly help the winner control their playoff destiny.
Elsewhere in District 10-1A, the Gordon Longhorns fell at home, 16-2, to the first-place Baird Bears (9-4, 6-2).
Baird jumped out to an early lead, thanks in part to a five-run second inning, and continued to score at least one run in every consecutive frame, until the game was called after the fifth.
Gordon got on the board in the bottom of the third when Humberto Estrada drove home runners on second and third base with a single to cut the Bears' lead to 7-2. But two more shutout innings spelled doom for the Longhorns, who registered six hits for the game to the Bears' 14.
Pitcher Seth Wheeler took credit for the loss in a five-strikeout performance. He allowed seven runs, five earned, and walked four through three innings of work.
Also pitching in relief roles were Chase Barfield, Matthew Stockstill and Seth Allen, who each pitched two-thirds of an inning and fanned one batter.
Barfield allowed five runs, four of which were earned, and three walks, while Stockstill also allowed three walks to go along with four runs, all earned.
Allen was the only Longhorn pitcher to allow no runs or walks in the game for a tidy stat line.
The 'Horns will continue district play today with a home game against the cross-county Graford Jackrabbits. Both teams are searching for their first district win, according to txhighschoolbaseball.com.
The Santo Ladycats (2-7) had a sour roadtrip to DeLeon, where they lost to the other Lady Cats, 21-1, in district play.