DeLeon wasted no time in putting the game out of reach with a 10-run first inning and an 11-run second before the game was called halfway through the third frame.
Ashleigh Kroll took the loss for Santo to fall to 1-4 on the season. She allowed 13 hits and five walks with no strikeouts.
Offensively, Jawnee Hess was Santo's only player to register a hit, while Haley DeShazo and Caitlin Pechacek both reached base on walks and Macie Fuller was hit by a pitch.
Pechacek scored Santo's lone run.
The Ladycats will take a short break before returning to softball action against Gorman in a road contest, Friday.